Ulcers are defined as abnormal breaks in the skin or mucous membranes. They can be caused by a wide number of pathologies and have a prevalence of approximately 1%.

The majority of ulcers (80%) have a venous origin, with other common causes including arterial insufficiency and diabetic-related neuropathy. Rarely, they can also be caused by infection, trauma, vasculitis or malignancy (typically squamous cell carcinoma).

It should be remembered that in patients who are less mobile, ulcers may also be caused by prolonged or excessive pressure over a bony prominence (pressure ulcers), leading to skin breakdown and eventual necrosis. In the hospital setting, these pressure ulcers should be managed by adequate mattresses to aid repositioning and good wound management.

This article will discuss the three main types of causes for ulcers – venous, arterial and neuropathic.

Key Points

  • Venous ulcers are shallow ulcers with a granulated base, often with other clinical features of venous insufficiency present
  • Neuropathic ulcers are painless ulcers over areas of abnormal pressure, often secondary to joint deformity in diabetics
  • Arterial ulcers are found at distal sites, often with well-defined borders and other evidence of arterial insufficiency

Venous Ulcers

A venous ulcer is caused by venous insufficiency. They often appear shallow with irregular borders and a granulating base, characteristically located over the medial malleolus.

They occur when retrograde flow in the superficial venous system causes venous dilatation, leading to pooling of blood distally. It is thought that this impedes oxygen delivery to the skin, eventually causing ulceration (typically over the paths of the long and short saphenous veins).

Risk Factors

The risk factors for developing a venous ulcer include:

  • Deep venous thrombosis
  • Pre-existing venous incompetence
    • Including varicose veins
  • Trauma
  • Pregnancy
  • Obesity

Clinical Features

Venous ulcers can be painful (particularly worse at the end of the day) and are often found in the gaiter region of the legs (Fig. 1). Associated symptoms include dry and itchy skin and distended aching veins.

On examination, there may be varicose veins with ankle or leg oedema, as well as features associated with venous insufficiency, including oedema, varicose eczema or thrombophlebitis, haemosiderin skin staining, lipodermatosclerosis, or atrophie blanche

Fig 1 - Venous Ulcers are typically shallow with a granulating base and irregular borders

Figure 1 – Venous Ulcers are typically shallow with a granulating base and irregular borders


The diagnosis of venous ulcers is clinical, with the underlying venous insufficiency confirmed by Duplex Ultrasound. Most commonly venous incompetence occurs at the sapheno-femoral or sapheno-popliteal junctions, although it may occur in any perforator.

An Ankle Brachial Pressure Index (ABPI) is sometimes required to exclude arterial disease before application of compression bandaging. If infection is suspected (i.e. erythematous or with purulent exudate) then consider microbiology swabs and antibiotics.


Conservative management for venous ulcers warrants leg elevation and increased exercise (promoting calf action). Emollients should be prescribed for any dry skin present and antibiotics prescribed if infected.

The mainstay of management is via 4-layered compression bandaging, changed once or twice every week. Importantly, the ABPI must be measured as at least greater than 0.7 before any bandaging is applied.

If there is concurrent varicose veins, these should be treated with radiofrequency ablation. Improving venous return will allow for the healing of the venous ulcers; failed endovascular therapy will then warrant surgical interventions

Arterial Ulcers

An arterial ulcer refers to an ulcer caused by a reduction in arterial blood flow, leading to decreased perfusion of the tissues and subsequent poor healing.

They often form as small deep lesions with well-defined borders and a necrotic base. They most commonly occur distally at sites of trauma and in pressure areas (e.g the heel).

Risk Factors

The main risk factors are those of peripheral arterial disease, including smoking, diabetes mellitus, hypertension, hyperlipidaemia, increasing age, positive family history, and obesity and physical inactivity

Clinical Features

A patient with a suspected arterial ulcer is likely to give a preceding history of intermittent claudication (pain when they walk) or critical limb ischaemia (pain at night).

The ulcer may be painful and often develops over a long period of time, with little to no healing (therefore no or little granulation tissue). Other associated signs include cold limbs, necrotic toes and hair loss.

On examination, the limbs will be cold and have reduced or absent pulses. In pure arterial ulcers, sensation is maintained (unlike neuropathic ulcers). Assess for signs of venous insufficiency, as some patients have mixed pathology.

Fig 2- Ischaemic ulcers: well defined edges in peripheral parts of limbs

Figure 2- Ischaemic ulcers, all showing well-defined edges in peripheral parts of limbs


Any suspected arterial ulcer warrants an Ankle Brachial Pressure Index (ABPI) measurement, which can further quantify the extent of any peripheral arterial disease (>0.9 = normal; 0.9-0.8 = mild; 0.8-0.5 = moderate; <0.5 = severe).

The anatomical location of any arterial disease can be assessed by clinical examination, followed by imaging. This includes duplex ultrasound, CT Angiography, and / or Magnetic Resonance Angiogram (MRA).


In the UK, NICE guidance states that any patient with critical limb ischaemia (i.e. those with ulcers) should be urgently referred for a vascular review. The management of such patients requires a combination of:

  • Conservative – All patients should be advised lifestyle changes, including smoking cessation, weight loss, and increased exercise (specific supervised exercise programmes are available).
  • Medical – Suitable pharmacological cardiovascular risk factor modification should also be prescribed, including statin therapy, an antiplatelet agent (aspirin or clopidogrel), and optimisation of blood pressure and glucose.
  • Surgical – Angioplasty (with or without stenting) or bypass grafting (usually for more extensive disease).
    • Any non-healing ulcers despite a good blood supply may also be offered skin reconstruction with grafts.

Neuropathic Ulcers

A neuropathic ulcer is one that occurs as a result of peripheral neuropathy. In peripheral neuropathy, there is a loss of protective sensation. which leads to repetitive stress and unnoticed injuries forming, resulting in painless ulcers forming on the pressure points on the limb. Concurrent vascular disease will often contribute to their formation and reducing healing potential.

Risk Factors

Neuropathic ulcers can develop with any condition with peripheral neuropathy, the most common being diabetes mellitus and B12 deficiency.

Ulcer risk is further compounded by any foot deformity or concurrent peripheral vascular disease.

Clinical Features

Patients with neuropathic ulcers typically have a history of peripheral neuropathy (although sometimes they may be unaware) or symptoms of peripheral vascular disease.

Other clinical manifestations of the neuropathy may include burning/tingling in legs (painful neuropathy), single nerve involvement (mononeuritis multiplex, such as CN III or median nerve), or amotrophic neuropathy (painful wasting of proximal quadriceps).

On examination, neuropathic ulcers are variable in size and depth, with a “punched out appearance” (Fig. 3). They occur most commonly on sites of pressure on feet (e.g. metatarsal heads or heels). Additionally, there may be a peripheral neuropathy (classically in a ‘glove and stocking’ distribution) with warm feet and good pulses (unless element of concurrent arterial disease).

Fig 3 - Neuropathic ulcers, showing the classic 'punched out' appearance

Figure 3 – Neuropathic ulcers, showing the classic ‘punched out’ appearance


Blood glucose levels should be checked (either random glucose or HbA1c %), in addition to serum B12 levels. Concurrent arterial disease should be assessed with an ABPI +/- duplex.

Signs of infection require a microbiology swab and any evidence of deep infection (e.g. visible bone or ulcers extending into joints), may warrant an X-ray to assess for osteomyelitis.


Many centres will have specialised diabetic foot clinics for patients with neuropathic ulcers, where they are managed via a full multidisciplinary (MDT) team.

Diabetic control should be optimised, targeting HbA1c <7%. Improved diet and increased exercise (within limits) should be encouraged, and any cardiovascular risk factors present managed accordingly. Ensure regular chiropody to maintain good foot hygiene and appropriate footwear provided (e.g. non-weight bearing shoes).

Any signs of infection will warrant swabs taken and antibiotics (e.g. flucloxacillin) started. Ischaemic or necrotic tissue may require surgical debridement. In severe cases, necrotic or infected digits may need amputation.

Charcot’s Foot

Neuropathic ulcers can be seen alongside Charcot’s foot. This is neuroarthropathy whereby a loss of joint sensation results in continual unnoticed trauma and deformity occurring. The deformity predisposes the patient to neuropathic ulcer formation.

Patients present with swelling, distortion, pain (typically less than may be expected with such a deformity), and loss of function. Any deformity causing the loss of the transverse arch is termed a “rocker-bottom” sole (Fig. 4).

Charcot’s foot requires a specialist review for consideration of off-loading abnormal weight, and sometimes immobilisation of the affected joint in plaster.

Fig 4 - Charcot foot: (A) initial arthropathy changes; and (B) progressive deformity over 2 years

Figure 4 – Charcot foot: (A) initial arthropathy changes; and (B) progressive deformity over 2 years


Question 1 / 4
What test must be performed before applying 4-layer compression bandaging for venous ulceration?


Question 2 / 4
Which of the following is not a cause of peripheral neuropathy?


Question 3 / 4
What antibiotic is commonly started for infected arterial ulcers, due to good coverage of Gram positive bacteria


Question 4 / 4
Which of the following clinical features is most associated with arterial ulcers?


Further Reading

The Current State of Critical Limb Ischemia: A Systematic Review
Farber A et al., JAMA Surgery

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