Hoarse Voice

A hoarse voice refers to a weak or altered voice. It is a relatively common presentation, and can represent a wide range of pathologies.

In this article, we shall look at the investigations and differential diagnoses to consider in a patient with a hoarse voice.


 

Investigations

Any patient presenting with a hoarse voice should undergo a flexible nasal endoscopy (FNE). FNE allows visualisation of the larynx and the vocal cords (Fig. 1), therefore key in identifying any underlying pathology. It can be performed in the outpatient clinic, with minimal preparation required.

Microlaryngobronchoscopy (MLB) is another procedure that allows for visualise the larynx, vocal cords, and the bronchi. Similar to FNE, is provides a good view of the structures, however MLB is performed in a theatre setting under general anaesthetic

Stroboscopy is used in specialist voice clinics and can be a very useful diagnostic test in vocal cord dysfunction. It involves the use of synchronised flashing lights to make vocal fold movements appear slower, allowing for complete assessment of their movement.

Figure 1 – The Vocal Cords, as viewed via flexible nasal endoscopy

The True Vocal Cords

The true vocal cords are responsible for producing voice by being able to abduct and adduct, through innervation from the recurrent and superior laryngeal nerve. Any pathology affecting the structure of the vocal cords or their innervation will result in hoarseness.

Figure 2 – Superior view of the intrinsic muscles of the larynx.


Differential Diangosis

There are a number of possible causes of hoarseness, including benign laryngeal conditions, infective, neurological, malignant, and functional.

Functional causes should be seen as a diagnosis of exclusion when no cause can be found, however it is a common cause for hoarseness.

Figure 3 – Vocal Cord Nodules as seen on FNE

Benign Laryngeal Conditions

  • Vocal cord nodules are commonly secondary to chronic phonotrauma (vocal abuse)
    • They are benign lesions that are frequently bilateral (Fig. 3), occurring at the junction between the anterior and middle third of the vocal folds.
    • Management is mainly from the Speech and Language Therapy (SALT) team, however in severe or resistant cases, surgical intervention may be warranted
  • Muscle tension dysphonia is caused by habitual misuse of the muscles of the larynx
    • Commonly present with a hoarse voice worsening towards the end of the day or following prolonged use.
    • Diagnosis can be confirmed via stroboscopy and the mainstay of management is from the SALT team
  • Vocal cord polyps are typically benign lesions, however unlike vocal cord nodules, they are normally unilateral and may need surgical excision to exclude malignancy.
  • Laryngeal papillomas are also benign lesions in the larynx, commonly caused by HPV infection
    • If left untreated, papillomas can grow to cause airway obstruction and hence need surgical excision or debulking. It is not uncommon for patients to need repeat procedures as papillomas can recur.
  • Reflux laryngitis is a cause of hoarseness caused by acid reflux resulting in inflammation of the larynx.
    • Clinical examination will often be unremarkable, but FNE will reveal an erythematous larynx. Further investigation may require an OGD and treatment will be with a PPI ± H. Pylori eradication therapy.
  • Reinke’s oedema is oedema of the vocal folds (Fig. 4). It is strongly linked to smoking in females. Smoking cessation and voice therapy are the mainstay of treatment.

Figure 4 – Oedematous vocal cords, as seen in Reinke Oedema

Infective

  • Laryngitis is inflammation of the vocal cords, commonly following respiratory tract infections
    • Clinical examination will be normal but FNE will reveal an inflamed larynx. This can be managed conservatively and should result in complete recovery.
  • Acute epiglottitis is infection of the epiglottis, further discussed here.

Neurological

A recurrent laryngeal nerve palsy can be caused by a wide variety of underlying causes, including thyroid cancer, lung cancer, aortic aneurysm, multiple sclerosis (MS), or stroke.

Extensive examinations are key to further delineating the underlying diagnosis such as neck examination and cranial nerve examination. Initial investigation if examination is unremarkable would be CT imaging from skull base to diaphragm to assess for any pathology affecting the recurrent laryngeal nerve.

Fig. 4 – Vocal Cord Paralysis during phonation and respiration

 

Key Points

  • Wide range of pathology can result in hoarseness, from inflammatory to neurological
  • All patients should undergo flexible nasal endoscopy to allow for the visualisation of the larynx and the vocal cords, before further investigations can occur

Quiz

Question 1 / 3
What is first line investigation for most cases of hoarseness?

Quiz

Question 2 / 3
Vocal cord nodules are commonly secondary to what?

Quiz

Question 3 / 3
Which muscle is responsible for the abduction of the vocal cords?

Results

Further Reading

Investigating the hoarse voice
PM Pretorius et al., The BMJ

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