Chronic otitis media (COM) is an inflammatory disorder of the middle ear. It is characterised by persistent or recurrent ear discharge.
Most classifications now separate chronic otitis media into two distinct types:
- Squamous – occurs due to retraction of the tympanic membrane and is associated with the formation of cholesteatoma
- Mucosal – occurs due to tympanic membrane perforation and subsequent inflammation of the middle ear mucosa; it is also known as chronic suppurative otitis media
In this article, we shall look at the risk factors, clinical features, and management of chronic squamous otitis media.
Squamous chronic otitis media can be congenital* or acquired, however the majority are acquired.
In acquired disease, the precise pathophysiology is unknown, but is thought to result from chronic negative middle ear pressure from Eustachian tube dysfunction.
The result is a pocket of space being left, termed a retraction pocket (Fig 1). These pockets are initially self-cleansing, but some may narrow, and trap keratinised squamous cell debris, leading to the formation of a cyst-like structure which may evolve into a cholesteatoma (Fig. 2).
*Congenital disease is seen in patients with no history of ear surgery, and no perforation or retraction of the tympanic membrane; indeed congenital cholesteatomas represent epidermoid cysts within the middle ear cavity
Thus, ‘cholesteatoma’ is a misnomer as there is no cholesterol or tumour-like process in the disease. However, the presence of super-added infection on the debris may lead to a purulent discharge.
It is not possible to predict with certainty which pockets will go on to form a cholesteatoma, those in the ‘attico-antral’ (postero-superior) aspect of the tympanic membrane are thought to be high-risk, whereas those in the ‘tubotympanic’ (antero-inferior) aspect are thought to be low-risk.
Cholesteatomas can induce an inflammatory process in the adjacent temporal bone. This may lead to local destruction of the ossicles (resulting in a conductive hearing loss), semicircular canals (leading to vertigo), cochlea (sensorineural hearing loss), and facial canal (facial nerve palsy).
In the most severe cases, there can be erosion into the intracranial cavity, which may cause life-threatening meningitis, intracranial abscesses, and sinus thrombosis.
Middle ear disease such as recurrent acute otitis media, Eustachian tube dysfunction, and prior otological surgery are all known risk factors for cholesteatoma. The disease also has a more aggressive clinical course in children.
In the ‘inactive’ phase of the disease, where retraction pockets are made, patients may be asymptomatic.
When cholesteatomas are formed, patients may present a conductive hearing loss. Purulent ear discharge can also occur, which may be resistant to topical antibiotics.
Any bony destruction of the cochlea may present with a sensorineural component, whilst other localised bony destruction may result in tinnitus, vertigo, or facial nerve palsy. Importantly, otalgia is not a common feature.
Diagnosis is made clinically during examination whereby a pearly, keratinized, or waxy mass in the attic region is seen on otoscopy (Fig. 2). These are best seen when a perforation of the tympanic membrane is present, providing a window into the middle ear.
As part of the workup, all patients should receive a pure-tone audiogram to objectively determine the extent and type of hearing loss.
A CT scan of the petrous temporal bone (Fig. 3) must be performed to guide clinical suspicion and for pre-operative surgical planning
The definitive management of a cholesteatoma is surgery, aiming to remove the entire cholesteatoma as otherwise it will recur.
Most surgical approaches involve creating a mastoid cavity, whereby the cholesteatoma is removed and the mastoid is “cleaned out” by drilling away the air cells. Access to the mastoid is traditionally made using a post-auricular or pre-auricular incision (although increasingly can be accessed endoscopically).
The ossicles can be reconstructed depending on the damage caused by the cholesteatoma. The aim of surgery is not to restore hearing but to halt progression of the destructive lesion and create a ‘safe and dry ear’.
- Squamous COM occurs due to retraction of the tympanic membrane and is associated with the formation of cholesteatoma
- Patients will present with a chronically discharging ear, in the absence of fever or otalgia
- Cholesteatomas can be visualised during clinical examination if suspected, and further assessed via CT imaging
- The definitive management of a cholesteatoma is with surgery