Chronic Mesenteric Ischaemia

Original Author: James Wolff
Last Updated: December 22, 2017
Revisions: 17

Chronic mesenteric ischaemia (CMI) is a lack of blood supply to the bowel which gradually deteriorates over time as a result of atherosclerosis in the coeliac trunk (CT), superior mesenteric artery (SMA), and/or inferior mesenteric artery (IMA). Retrospective autopsy data has shown that the mortality rate in the general population from mesenteric ischaemia is <0.01%

In this article, we shall look at the causes, clinical features and management of the patient with chronic mesenteric ischaemia.


The gradual buildup of atherosclerotic plaque causes narrowing of the blood vessel lumen, reducing blood flow and resulting in ischaemia to the bowel. The degree of communication within the visceral blood supply means that in the majority of circumstances at least two of the CT, SMA, and IMA must be affected.

When there is an increased demand on the blood supply (such as when eating) or reduction in supply (i.e. hypovolemic states) in patients with chronic mesenteric ischaemia, a transient ischemia of the bowel occurs, resulting in symptom onset.

Chronic mesenteric ischaemia occurs mostly in patients >60yrs and more commonly in females. Patients with atherosclerotic disease in the mesenteric vessels are often asymptomatic, and as such the condition is typically under-reported. However the prevalence of atherosclerotic involvement in the mesenteric vessels has been reported between 30-50%.

Fig 1- The arerial supply from the superior mesenteric artery to the midgut

Figure 1 – The arterial supply from the superior mesenteric artery to the midgut

Risk Factors

The main risk factors for chronic mesenteric ischaemia are smoking, hypertension, diabetes mellitus, and hypercholesterolemia.

Clinical Features

The classical set of symptoms associated with chronic mesenteric ischaemia are:

  • Postprandial pain – classically occurring around 10mins-4hrs after eating
    • This may be associated with a fear of eating (sitophobia), as eating becomes linked to pain
  • Weight loss – a combination of decreased calorie intake and malabsorption
  • Concurrent vascular co-morbidities, e.g. previous MI, stroke, or PVD

Other less specific symptoms may include change in bowel habit (typically loose), nausea, and vomiting. Examination findings are often non specific; evidence of malnutrition/cachexia, generalised abdominal tenderness, and abdominal bruits may be present.

Differential Diagnosis

Often a patient has undergone several other investigations for other pathologies before the diagnosis of chronic mesenteric ischaemia is reached.

Possible differentials for the chronic non-specific abdominal pain may include chronic pancreatitis, gallstone pathology, peptic ulcer disease, or upper GI malignancy


Blood tests will routinely be normal, yet typically routine bloods (including FBC, U&Es, and LFTs) will have been performed prior to the diagnosis of chronic mesenteric ischaemia being reached. Anaemia may be confounding symptoms and cardiovascular risk profile factors (lipids, glucose) may be abnormal.

CT angiography is the diagnostic test of choice, providing good anatomical views of all vessels and can help gauge any intervention required; catheter angiography previously was the gold standard imaging modality but is now used less due to the improvement of CT angiography.


Fig 3 - Angioplasty and stenting. This is one of the surgical options available for the treatment of chronic limb ischaemia.

Figure 3 – A diagramatic representation of angioplasty with stenting

Management plans for chronic mesenteric ischaemia are typically made jointly between the interventional radiologists and vascular surgeons.

Patients should be started on best medical therapy, including an antiplatelet agent and a statin (if not already), alongside advice promoting weight loss, increasing exercise, and smoking cessation. Stabilising the atherosclerotic plaque with such agents will prevent subsequent worsening of the disease.

Surgical Treatment

Surgical intervention is warranted in severe disease, progressive disease, or presence of debilitating symptoms (including signs of weight loss or malabsorption). The ultimate decision about which approach to take will depend on the location and severity of the disease, alongside patient factors and co-morbidities:

  • Endovascular procedures (more common) – consists of mesenteric angioplasty with stenting
  • Open procedures (less common) – consists of an endartectomy or a bypass procedure.

Mesenteric Angioplasty

Mesenteric angioplasty is typically performed percutaneously, through either the femoral artery or brachial/axillary artery, allowing a catheter to be passed to the appropriate vessel under radiological guidance. A small balloon is expanded to dilate the vessel (Fig. 3), with any stent deployed if required.

Such procedures provide a shorter hospital stay with faster mobilisation for the patient. The main complications from endovascular intervention are haematoma at the arterial puncture site, risk of embolisation, and vessel perforation.


The main complications of chronic mesenteric ischaemia are bowel infarction with necrosis or malabsorption. Many patients will also have concurrent cardiovascular disease which will also require suitable medical management and optimisation.

Prognosis after intervention is good, with comparable results in terms of relief of symptoms between open surgery and endovascular methods.

Key Points

  • Chronic mesenteric ischaemia is reduced blood supply to the bowel, often associated in patients with concurrent cardiovascular disease
  • Patients will complain of post-prandial pain and weight loss, in an otherwise unremarkable examination
  • Definitive diagnosis often comes from CT angiography
  • Patients with chronic mesenteric ischaemia can be treated with endovascular or open procedures, if deemed suitable, and should have any cardiovascular risk factors addressed accoridingly


Question 1 / 4
Which of the following is a risk factor for chronic mesenteric ischaemia?


Question 2 / 4
What is the main blood supply to the ileum


Question 3 / 4
Which of the following patient's has a presentation most in keeping with chronic mesenteric ischaemia?


Question 4 / 4
What is gold-standard diagnosis for chronic mesenteric ischaemia


Further Reading

Mesenteric Ischemia
Clair DG et al., NEJM

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