Post-Operative Ileus

Risk Factors

• Patient Factors
  • Increased age
  • Electrolyte derangement (e.g. Na⁺, K⁺and Ca²⁺ derangement)
  • Neurological disorders (e.g. Dementia or Parkinson’s Disease)
  • Use of anti-cholinergic medication
• Surgical Factors
  • Use of opioid medication
  • Extensive intra-operative intestinal handling
  • Peritoneal contamination (by free pus or faeces)
  • Intestinal resection

Clinical Features

A post-operative ileus is simply a delay in the return of normal bowel function. As a result, the symptoms of post-operative ileus may be the same as those of a mechanical obstruction.

Common presenting features therefore are:

• Failure to pass flatus or faeces
• Sensation of bloating and distention
• Nausea and vomiting (or high NG output)

On examination, there will be abdominal distention and absent bowel sounds (whereas in mechanical obstruction there are classically “tinkling” bowel sounds present)

Investigations

In the patients with suspected post-operative ileus, the aim of the investigations are to rule out more serious pathologies and determine any underlying cause.

Initial routine bloods should be taken, including FBC and CRP (to check inflammatory markers), and U&Es (as fluid shifts can occur within the adynamic bowel leading to AKI). The patient’s electrolytes, including Ca2+, PO₄³⁻, and Mg2+, should also be checked and corrected accordingly.

A CT scan abdomen and pelvis (often with oral contrast) will confirm the diagnosis (Fig. 1) and importantly also rule out any intra-abdominal collections or anastomotic leaks.

By Hellerhoff [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)], from Wikimedia Commons

Figure 1
CT scan (coronal view) showing small bowel ileus

Management

As long as serious pathology (e.g. anastomotic leak) has been excluded, the management of post-operative ileus is often conservative.

Any established postoperative ileus should be initially managed with:

• Nil-by-mouth (NBM), ensuring adequate intravenous fluids prescribed
  • Start a strict fluid-balance chart to monitor input-output
• Insertion of a nasogastric tube (Fig. 2), on free drainage with regular aspirations
• Daily bloods, including electrolytes
  • Correct any electrolyte abnormalities and monitor for acute kidney injury
• Encourage mobilisation as tolerated
• Reduce opiate analgesia and any other bowel mobility reducing medication

It is important to warn patients that once it does settle, they may well have very watery stool for the first few bowel movements.

In patients with a prolonged ileus, consider early total parenteral nutrition (TPN) to ensure optimal nutrition is maintained

By Cancer Research UK) [CC BY-SA 4.0]

Figure 2
A nasogastric tube should be inserted as part of the management for post-operative ileus

Prophylactic Measures

To reduce the risk of developing post-operative ileus, preventive steps include:

• Minimise intra-operative intestinal handling
• Avoid fluid overload (causing intestinal oedema)
• Minimise opiate use
• Encourage early mobilisation