Deep Venous Insufficiency

Risk Factors

Risk factors for DVI include increasing age, female gender, pregnancy, previous DVT or phlebitis, obesity, and smoking.

Those in jobs which involve long periods of standing or with a strong family history of venous disease are also at risk.

Clinical Features

Patients may report chronically swollen lower limbs, which can become aching, pruritic, and painful. They may also report venous claudication, characterised by a bursting pain and tightness on walking which resolves on leg elevation.

On examination, several signs can indicate underlying DVI, including varicose eczema (dry and scaly skin), thrombophlebitis, haemosiderin skin staining, lipodermatosclerosis*, or atrophie blanche**

Patients will have varying degrees of dependent pedal oedema and may also have venous ulcers, which are typically found over the medial malleolus

*A tapering of legs above ankles, an “inverted champagne bottle” appearance **Localised round, white atrophic regions surrounded by dilated capillaries

By TeachMeSeries Ltd (2026)

Figure 1
(A) Haemosiderin deposition with lipodermatosclerosis (B) Pitting oedema with varicose eczema

Patients who have had a prior DVT may present with symptoms of Post-Thrombotic Syndrome*, including heaviness, cramps, pain, pruritis, and paraesthesia, and clinical signs of pretibial oedema, skin induration, hyperpigmentation, venous ectasia, redness, and ulceration.

*The Villalta scale can be used to assess progression with treatment of post-thrombotic syndrome

Differential Diagnosis

Differential diagnoses to consider in patients who present with leg swelling include renal, hepatic, or cardiac disease, all of which require thorough work-up and investigation before being excluded. Any ulceration will need careful evaluation of the underlying cause.

Investigations

The primary investigation for diagnosing DVI is a Doppler ultrasound scan, allowing the assessment for the extent of venous reflux*, any sites of stenosis, and the presence of a DVT or varicose veins.

Routine blood tests may be useful to further exclude other potential aetiologies, including FBC, U&Es, and LFTs, BNP (+/- an ECHO if indicated).

An essential component of the investigations is documentation of foot pulses and ankle brachial pressure index as this will be required to determine suitability for compression therapy.

*If there is evidence of a venous occlusion or reflux in the pelvis as characterised by poor flow wave forms in the femoral veins or varicosities over the buttocks/perineum, then an MR Venogram may be performed

Management

Identifying deep venous insufficiency early is essential, as early treatment may reduce long-term complications and prevent irreversible damage. Management can be either conservative or surgical.

The mainstay of conservative treatment is via compression stockings (Fig. 2). If the patient has a venous ulcer then they should be started in full compression treatment, such as with 4-layer bandage, short stretch bandage, stockings, or compression wrap. Patients without ulceration can be started in light compression stockings (Class 1) and build up (to Class 4) as required, depending on symptoms.

If symptoms remain, elevating the feet above the level of the precordium can reduce symptoms and disease progression.

Lentpjuve / CC BY-SA (https://creativecommons.org/licenses/by-sa/4.0)

Figure 2
Compression stockings, both below knee and above knee

Surgical Management

Surgical management of deep venous insufficiency is variable. There is minimal evidence in the benefit for valvuloplasty and this is not routinely undertaken.

Patients with severe post-thrombotic syndrome with an occluded iliac vein may be suitable for deep venous stenting; this procedure is reserved for patients with the most severe symptoms* despite maximal conservative therapy, and requires veins with a good inflow and outflow at the site around where the stent is placed.

*When undertaken in the right patient, stent patency is over 80% out to 3 years, with significant improvements in quality of life

Complications

Common long-term complications of DVI include swelling, recurrent cellulitis, chronic pain and ulceration (Fig. 3). More serious but less common complications include deep vein thrombosis, secondary lymphoedema, and varicose veins.

A Marjolin ulcer is a rare type of cutaneous squamous cell carcinoma (SCC) developing at the site of severe or recurrent inflammation (such as in venous insufficiency). They typically present as non-healing ulcers, steadily increasing in size and have excessive granulation tissue, often bleeding easily on contact, and be painful.

Nini00, CC BY-SA 3.0 <https://creativecommons.org/licenses/by-sa/3.0>, via Wikimedia Commons

Figure 3
Venous ulceration