Aortic Dissection

Original Author: Aimee Rowe
Last Updated: November 20, 2016
Revisions: 16

Aortic dissection occurs when a tear in the intimal layer (innermost) of the aortic wall causes blood to flow between the layers of the wall of the aorta, splitting the layers apart.

It can be defined as acute (when diagnosed ≤14 days) or chronic (when diagnosed >14 days).

In this article, we shall look at the classification, clinical features and management of aortic dissection.

Fig 1 - Histopathological image of thoracic aortic dissection. Blood enters the arterial wall and separates the tunica intima from the tunica media.

Fig 1 – Histopathological image of thoracic aortic dissection. Blood enters the arterial wall and separates the tunica intima from the tunica media.


Classification

Aortic dissections from the initial intimal tear can progress distally, proximally, or in both directions from the point of origin.

Anterograde dissections propagate towards the iliac arteries, and retrograde dissections propagate towards the aortic valve (at the root of the aorta). Retrograde dissections can result in prolapse of the aortic valve, bleeding into the pericardium and cardiac tamponade.

Thoracic aortic dissections are classified anatomically by two systems; Stanford and DeBakey.

DeBakey Classification

The DeBakey classification groups aortic dissections anatomically:

  • Type I  – originates in the ascending aorta and propagates at least to the aortic arch and often beyond. They are typically seen in patients under 65 and carry the highest mortality.
  • Type II – confined to the ascending aorta and is seen classically in elderly patients with atherosclerotic disease and hypertension.
  • Type III – originates to the left of the subclavian artery in the descending aorta. Type III can be subdivided into IIIa which extends distally to the diaphragm and IIIb which extends beyond the diaphragm into the abdominal aorta.

Stanford Classification

The Stanford classification divides aortic dissection into two groups, A and B:

  • Group A – includes DeBakey Types I and II and involves the ascending aorta, aortic arch and can propagate to the descending aorta; the tear can originate anywhere along this path.
  • Group B – dissections do not involve the ascending aorta and include DeBakey Type III.
Fig 2 - The DeBakey classification of aortic dissection.

Fig 2 – The DeBakey classification of aortic dissection.

Risk Factors

There are certain factors associated with an increased risk of developing an aortic dissection:

  • Hypertension
  • Atherosclerotic disease
  • Male
  • Caucasian
  • Connective tissue disorder (Marfan’s syndrome and Ehler’s-Danlos syndrome)
  • Biscuspid aortic valve

As a general rule, younger cases often have associated connective tissue disorders, whilst older patients are more likely to have an underlying associated hypertension or atherosclerosis.


Clinical Features

The characteristic presentation of an aortic dissection is of a tearing or stabbing chest pain, which can radiate depending on the anatomy of the dissection, particularly to the back. However, the diagnosis can be difficult to establish acutely and may prove to be a more subtle presentation.

On examination, the patient may present in shock, secondary to hypovolaemia from blood loss into the dissection, or cardiogenic in origin from severe aortic regurgitation or pericardial tamponade.

The most common clinical signs include tachycardia, hypotension, a new aortic regurgitation murmur, or signs of end-organ hypoperfusion (such as reduced urine output or deteriorating conscious level). They may also have neurological sequelae of the dissection, such as paraplegia.


Differential Diagnosis

Thoracic aortic dissection will often present as chest pain, a presenting problem that has multiple differential diagnoses:

  • Myocardial infarction –  classically crushing and central chest pain, with signs of cardiac ischaemia on ECG and / or raised serum Troponin levels.
  • Pulmonary embolism – dyspnoea will be a prominent feature and ABG will show hypoxia, confirm with CTPA or V/Q scan.
  • Pericarditis – classically pleuritic chest pain, with the ECG showng diffuse ST elevation as well as potential pericardial rub on auscultation.
  • Musculoskeletal back pain – the patient will not present with systemic signs of shock and will be tender to palpation of the chest wall or paraspinal muscles.

Investigations

Baseline blood tests should include a FBC, U&Es, LFTs, troponin, coagulation, and cross match 6U, with an ABG also taken (especially noting the lactate, as an indication of organ perfusion). An ECG is essential to exclude any cardiac pathology.

Imaging

A computed tomography (CT) angiogram is recommended to diagnose aortic dissection as first line. This will also allow classification, establish the anatomy of the dissection and assist surgical planning.

A transoesophogeal ECHO can also provide useful information about the thoracic aorta but is operator dependent.

Fig 3 - CT Chest of Stanford Type B Aortic Dissection

Fig 3 – CT Chest of Stanford Type B Aortic Dissection


Management

Urgent initial assessment is required, as for any other critcially ill surgical patient. Ensure airway management, oxygenation, large bore proximal IV access and fluid resuscitation; the target systolic pressure in these patients should be 100-120mmHg and a target heart rate of 60-80bpm. Catheterise the patient and start a fluid balance.

Stanford Type A dissections should be managed surgically in the first instance, if possible, and carry a worse prognosis than Type B dissections. Any uncomplicated Type B dissections can usually be managed medically.

Type A Dissections

Type A dissections carry a high mortality if left untreated and these cases should be discussed urgently with a cardiac or vascular surgeon. They will most likely require transfer to a cardiothoracic centre.

The surgery involves removal of the ascending aorta (with or without the arch) and replacement with synthetic graft, such as Dacron. If the dissection has damaged the suspensory apparatus of the aortic valve this will also require repair.

Any additional branches of the aortic arch that are involved will require reimplanation into the graft (i.e. brachiocephalic artery, left common carotid artery, left subclavian artery), with long Type A dissections involving the descending and possibly abdominal aorta may require staged procedures with both open and endovascular treatment, however this results in a risk of spinal cord ischaemia.

Type B Dissections

Uncomplicated Type B dissections are best managed medically, with good survival rates. First line treatment is management of any hypertension with beta blockers, such as propranolol or metoprolol IV; calcium channel blockers are second line therapy.

Research is ongoing as to the benefit of endovascular repair in these patients and medical management remains gold standard. Surgical intervention in Type B dissections will be determined on the basis of complications, such as visceral or limb ischemia, refectory pain or uncontrollable hypertension. Any surgical repair attempted is usually endovascular with a stent graft.

Type B dissections can go on to be chronic, with continued leakage into the dissection, even if a stent has been placed. The most common complication of chronic disease is the formation of an aneurysm. These present further surgical problems, with open repair being complex and endovascular repair offering a better survival chance.

Long Term Management

All patients need lifelong antihypertensive therapy and surveillance imaging, due to the high risk of developing further dissection or other complications. Imaging would usually be at one, three and 12 months after discharge, with further scans at 6-12 month intervals depending on the size of the aorta.


Complications

Any complications that arise depend on the site and spread of the dissection into the aortic branches, damaging end organs. Consequently, complications that can occur include:

  • Aortic rupture
  • Aortic regurgitation
  • Myocardial ischaemia (2to coronary artery dissection)
  • Cardiac tamponade
  • Stroke or paraplegia (2to cerebral artery or spinal artery involvement)

Mortality remains high, with over 20% of cases dying before reaching hospital, however early diagnosis, intervention, and blood pressure control significantly improves the prognosis

Further Reading

Management of acute aortic dissection
Nienaber CA et al., The Lancet

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